{"product_id":"erdomed-300-mg-10-capsule-angelini","title":"Erdomed 300 mg, 10 capsule, Angelini","description":"\u003cp class=\"text\"\u003e\u003cstrong\u003eErdomed 300 mg, 10 capsule, Angelini\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eIndicatii\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eTratament secretolitic in afectiunile acute si cronice bronhopulmonare, care sunt insotite de o tulburare a productiei si transportului de mucus.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eDozaj\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eAdulti (inclusiv varstnici): se administreaza 300 mg erdosteina (1 capsula) de 2 sau 3 ori pe zi, inainte de mese.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eCapsulele se inghit intregi, cu lichid.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eCopii si adolescenti: se administreaza alte forme farmaceutice, adecvate varstei.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eInsuficienta hepatica usoara pana la moderata: se reduce doza la 300 mg erdosteina (1 capsula) pe zi.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDurata tratamentului trebuie individualizata.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eContraindicatii\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eAUTORIZATIE DE PUNERE PE PIATA NR. 1120\/2008\/01-02\u003c\/p\u003e\n\u003cp class=\"text\"\u003eAnexa 2\u003c\/p\u003e\n\u003cp class=\"text\"\u003eRezumatul caracteristicilor produsului\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHipersensibilitate la erdosteina sau la oricare dintre excipienti,\u003c\/li\u003e\n\u003cli\u003eInsuficienta hepatica severa,\u003c\/li\u003e\n\u003cli\u003eInsuficienta renala severa (clearance-ul creatininei sub 25 ml\/min)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eAtentionari\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eIn insuficienta hepatica usoara pana la moderata este necesara reducerea dozei. (vezi si pct. 4.2).\u003c\/p\u003e\n\u003cp class=\"text\"\u003eIn insuficienta renala usoara pana la moderata erdosteina trebuie administrata cu prudenta putand fii necesara reducerea dozei.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eSe administreaza cu prudenta la pacientii cu ulcer gastro-duodenal.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eFluidificarea brutala a secretiilor poate determina inundarea bronhiilor la bolnavii incapabili sa expectoreze (impunandu-se bronhoaspiratie de urgenta).\u003c\/p\u003e\n\u003cp class=\"text\"\u003ePrin cresterea volumului secretiilor bronsice, erdosteina poate accentua reflexul de tuse. Aparitia tusei productive in timpul tratamentului cu erdosteina nu trebuie inhibata prin administrarea de antitusive.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eInteractiuni\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eNu se cunosc pana in prezent interactiuni cu alte medicamente.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eErdosteina se poate administra concomitent cu antibiotice, precum amoxicilina, ampicilina, claritromicina, ciprofloxacina sau eritromicina, cat si cu medicamente bronhodilatatoare (salbutamol, teofilina).\u003c\/p\u003e\n\u003cp class=\"text\"\u003eNu se recomanda asocierea Erdomed cu antitusive sau medicamente care scad secretia bronsica (parasimpatolitice).\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eSarcina\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eStudiile la animale nu au evidentiat efecte daunatoare directe sau indirecte asupra sarcinii, dezvoltarii embrionare\/fetale, nasterii sau dezvoltarii post-natale (vezi pct. 5.3). Deoarece nu sunt disponibile date privind administrarea la gravide sau excretia in laptele matern, nu se recomanda administrarea erdosteinei in timpul sarcinii si alaptarii.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eCondus auto\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eErdomed nu are nici o influenta asupra capacitatii de a conduce vehicule sau de a folosi utilaje.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eReactii adverse\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eOcazional pot sa apara tulburari gastro-intestinale (epigastralgii, greata, varsaturi, constipatie sau diaree), tulburarea simtului gustativ (disgeuzie temporara sau ageuzie) si uscaciunea gurii.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eRar, au fost observate cazuri de urticarie si eruptii cutanate si, foarte rar, cazuri de cefalee.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eRaportarea reactiilor adverse\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDaca manifestati orice reactii adverse, adresati-va medicului dumneavoastra sau farmacistului. Acestea includ orice reactii adverse nementionate in acest prospect. De asemenea, puteti raporta reactiile adverse direct prin intermediul sistemului national de raportare, ale carui detalii sunt publicate pe web-site-ul Agentiei Nationale a Medicamentului si a Dispozitivelor Medicale\u003c\/p\u003e\n\u003cp class=\"text\"\u003ehttp:\/\/www.anm.ro. Raportand reactiile adverse, puteti contribui la furnizarea de informatii suplimentare privind siguranta acestui medicament.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eSupradozaj\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eNu s-a raportat nici un caz de supradozaj.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eAtunci cand sunt ingerate doze mari de Erdomed, este asteptata aparitia mai frecventa si de intensitate crescuta a simptomelor mentionate la reactii adverse, in special cele gastrointestinale. Nu se cunoaste un antidot specific pentru supradozajul erdosteinei.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eProprietati farmacodinamice\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eGrupa farmacoterapeutica: Mucolitice, codul ATC: R05CB15\u003c\/p\u003e\n\u003cp class=\"text\"\u003eErdosteina este un mucolitic care, dupa administrare orala, reduce vascozitatea secretiilor bronsice si favorizeaza eliminarea acestor secretii, usurand astfel respiratia. In plus, datorita proprietatilor oxidoreducatoare, erdosteina poate preveni eliberarea radicalilor liberi de oxigen, ceea ce permite mentinerea activitatii alfa-1-antitripsinei, fiind astfel antagonizata activitatea crescuta a elastazei.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eErdosteina are doi atomi de sulf care, dupa metabolizare hepatica, apar ca grupari libere de sulfhidril. Studiile farmacologice au demonstrat ca erdosteina isi manifesta proprietatile mucolitice si antioxidante numai dupa ce aceste grupari sulfhidril devin libere ca urmare a proceselor de metabolizare hepatica.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eVascozitatea secretiilor bronsice depinde in principal de gradul de legare a glicoproteinelor pe care le contin acestea. Glicoproteinele din compozitia secretiilor bronsice sunt legate intre ele prin punti disulfidice. Prin procese de oxidoreducere, gruparile libere de sulfhidril determina ruperea legaturilor disulfidice din structura glicoproteinelor, reducand astfel vascozitatea secretiilor bronsice. Mucusul bronsic astfel fluidificat poate fi eliminat mai usor. In plus, prin fluidificarea mucusului bronsic foarte vascos, erdosteina faciliteaza si penetrarea mai profunda a amoxicilinei la nivelul structurilor acestui mucus, ceea ce determina instalarea mai rapida a efectului antibioticului.\u003c\/p\u003e\n\u003cp class=\"text\"\u003e\u003cstrong\u003eProprietati farmacocinetice\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"text\"\u003eAbsorbtie si metabolizare\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDupa administrarea orala, erdosteina este rapid absorbita de la nivelul tractului gastro-intestinal si metabolizata hepatic, rezultand cel putin trei metaboliti activi: Metabolit I (N-tiodiglicolil homocisteina), Metabolit II (N-acetil homocisteina) si Metabolit III (homocisteina). Acesti metaboliti contin grupari libere SH.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eConcentratia plasmatica maxima a substantei ramase nemodificate si cea a metabolitilor sai activi este atinsa dupa o perioada cuprinsa intre una si trei ore. Daca erdosteina se administreaza concomitent cu alimente, concentratiile plasmatice maxime sunt atinse dupa o perioada de timp mai mare. Concentratia maxima plasmatica si gradul de absorbtie raman neschimbate.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eEliminare\u003c\/p\u003e\n\u003cp class=\"text\"\u003eErdosteina si metabolitii sai sunt eliminati in principal renal sub forma de sulfati si o mica parte prin fecale. Timpul de injumatatire plasmatica este de 1-2 ore.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDate preclinice de siguranta\u003cbr\u003eDatele preclinice indica o toxicitate scazuta a erdosteinei.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eToxicitate acuta\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDL50 (soarece, sobolan) oral mai mult decat 5000 mg\/kg DL50 (sobolan) IP mai mult decat 5000 mg\/kg\u003c\/p\u003e\n\u003cp class=\"text\"\u003eDL50 (soarece) IV mai mult decat 3500 mg\/kg\u003c\/p\u003e\n\u003cp class=\"text\"\u003eToxicitate cronica\u003c\/p\u003e\n\u003cp class=\"text\"\u003eStudiile efectuate pe durata de pana la sase luni utilizand doua specii de animale (sobolan, caine), nu au evidentiat aparitia unor efecte toxice dupa administrarea dozelor orale maxime, care corespund la 15, respectiv 17 doze terapeutice maxime zilnice administrabile la om.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eMutagenitate\u003c\/p\u003e\n\u003cp class=\"text\"\u003eNu s-a semnalat potential mutagen atribuit erdosteinei in nici unul din testele de mutagenitate efectuate in vitro si in vivo, cu sau fara metabolizare.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eToxicitate asupra functiei de reproducere\u003c\/p\u003e\n\u003cp class=\"text\"\u003eTestele efectuate la sobolan si iepure folosind dozele maxime orale, care corespund la 58, respectiv 77 doze terapeutice maxime zilnice administrabile la om, nu au indicat nici un risc teratogen, embriotoxic sau de inhibare a fertilitatii. Au fost administrate doze de pana la 1000 mg\/kg la sobolani si de pana la 250 mg\/kg la iepuri, fara nici o evidenta a efectelor negative materne sau embriotoxice.\u003c\/p\u003e\n\u003cp class=\"text\"\u003eCarcinogenitate\u003c\/p\u003e\n\u003cp class=\"text\"\u003eNu au fost efectuate studii privind carcinogenitatea erdosteinei.\u003c\/p\u003e","brand":"Farmacia de acasa 🍀","offers":[{"title":"Default Title","offer_id":54983589396862,"sku":"","price":10.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0903\/8069\/7982\/files\/Screenshot2025-02-01at11.29.42.png?v=1738409414","url":"https:\/\/farmaciadeacasa.myshopify.com\/products\/erdomed-300-mg-10-capsule-angelini","provider":"Farmacia de acasa 🍀","version":"1.0","type":"link"}